Gilead’s drug remdesivir is not recommended for patients hospitalised with COVID-19, regardless of how ill they are, as there is no evidence it improves survival or reduces the need for ventilation, a World Health Organization panel said on Friday.“The … panel found a lack of evidence that remdesivir improved outcomes that matter to patients such as reduced mortality, need for mechanical ventilation, time to clinical improvement, and others,” the guideline said.The advice is another setback for the drug, which grabbed worldwide attention as a potentially effective treatment for COVID-19 in the summer after early trials showed some promise.
Remdesivir doesn’t help COVID-19 patients recover, WHO study says
At the end of October, Gilead cut its 2020 revenue forecast, citing lower-than-expected demand and difficulty in predicting sales of remdesivir. Story continues below advertisement
That same month, the WHO gave its first warning about remdesivir, saying a COVID-19 solidarity trial found it was not effective in preventing the death of patients infected with the virus and does not help them recover.The antiviral is one of only two medicines currently authorised to treat COVID-19 patients across the world, but a large WHO-led trial known as the Solidarity Trial showed last month that it had little or no effect on 28-day mortality or length of hospital stays for COVID-19 patients.
Coronavirus: Canada secures 150,000 vials of Remdesivir with Gilead Sciences, McKesson Canada
Coronavirus: Canada secures 150,000 vials of Remdesivir with Gilead Sciences, McKesson Canada – Sep 22, 2020
The medication was one of the drugs used to treat U.S. President Donald Trump’s coronavirus infection, and had been shown in previous studies to have cut time to recovery. It is authorised or approved for use as a COVID-19 treatment in more than 50 countries.
Trump turns to blocking state certification of U.S. election results after court losses
Trump’s efforts to challenge election flounder as Georgia recount confirms Biden win
[ Sign up for our Health IQ newsletter for the latest coronavirus updates ]
Gilead has questioned the Solidarity Trial’s results. Story continues below advertisement
“Veklury is recognised as a standard of care for the treatment of hospitalised patients with COVID-19 in guidelines from numerous credible national organisations,” Gilead said in a statement, referring to the drug’s brand name.“We are disappointed the WHO guidelines appear to ignore this evidence at a time when cases are dramatically increasing around the world and doctors are relying on Veklury as the first and only approved antiviral treatment for patients with COVID-19.”
Remdesivir cut coronavirus recovery time by 5 days, company’s final study suggests
The WHO’s Guideline Development Group (GDG) panel said its recommendation was based on an evidence review that included data from four international randomised trials involving more than 7,000 patients hospitalised with COVID-19.After reviewing the evidence, the panel said, it concluded that remdesivir, which has to be given intravenously and is therefore costly and complex to administer, has no meaningful effect on death rates or other important outcomes for patients.“Especially given the costs and resource implications associated with remdesivir …the panel felt the responsibility should be on demonstrating evidence of efficacy, which is not established by the currently available data,” it added.
Health Matters: Health Canada gives remdesivir the green light
Health Matters: Health Canada gives remdesivir the green light – Jul 29, 2020
The latest WHO advice comes after one of the world’s top bodies representing intensive care doctors said the antiviral should not be used for COVID-19 patients in critical care wards. Story continues below advertisement
The WHO’s recommendation, which is not binding, is part of its so-called “living guidelines” project, designed to offer guidance for doctors to help them make clinical decisions about patients in fast-moving situations such as the COVID-19 pandemic. The guidelines can be updated and reviewed as new evidence and information emerges.The panel said, however, that it supported continued enrolment into clinical trials evaluating remdesivir in patients with COVID-19, which it said should “provide higher certainty of evidence for specific groups of patients.”
Health Canada authorizes remdesivir to treat severe COVID-19
The recommendation may raise further questions about whether the European Union will need the 500,000 courses of the antiviral worth 1 billion euros it ordered last month.In July, Health Canada approved the use of remdesivir for treating severe COVID-19 cases. The government secured 150,000 vials of the drug for use in September.(Reporting by Kate Kelland; Additional reporting by Mrinalika Roy in Bengaluru; Editing by Kirsten Donovan and Stephen Coates)
View link »